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Polyarteritis nodosa
Systemic necrotizing inflammation of medium-sized muscular arteries / From Wikipedia, the free encyclopedia
Polyarteritis nodosa (PAN) is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.[3] Small aneurysms are strung like the beads of a rosary,[4] therefore making this "rosary sign" an important diagnostic feature of the vasculitis.[5] PAN is sometimes associated with infection by the hepatitis B or hepatitis C virus.[6] The condition may be present in infants.[7]
Quick Facts Other names, Specialty ...
Polyarteritis nodosa | |
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Other names | Panarteritis nodosa,[1] Periarteritis nodosa,[1] Kussmaul disease, or Kussmaul-Maier disease,[2] |
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Polyarteritis nodosa: Macroscopic specimen of the heart with abundant adipose tissue and nodular thickened coronary vessels | |
Specialty | Immunology, rheumatology ![]() |
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PAN is a rare disease.[6] With treatment, five-year survival is 80%; without treatment, five-year survival is 13%. Death is often a consequence of kidney failure, myocardial infarction, or stroke.[8]