![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/9/93/Bicalutamide.svg/640px-Bicalutamide.svg.png&w=640&q=50)
Nonsteroidal antiandrogen
Antiandrogen with a nonsteroidal chemical structure / From Wikipedia, the free encyclopedia
A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure.[1][2][3] They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT).[2][3] NSAAs are used in the treatment of androgen-dependent conditions in men and women.[2] They are the converse of steroidal antiandrogens (SAAs), which are antiandrogens that are steroids and are structurally related to testosterone.[2][3]
Quick Facts Class identifiers, Synonyms ...
Nonsteroidal antiandrogen | |
---|---|
Drug class | |
![]() Bicalutamide, the most widely used nonsteroidal antiandrogen and the most widely used antiandrogen in prostate cancer. | |
Class identifiers | |
Synonyms | Nonsteroidal androgen receptor antagonists |
Use | Prostate cancer; Acne; Hirsutism; Seborrhea; Pattern hair loss; Hyperandrogenism; Transgender hormone therapy; Male precocious puberty; Priapism |
ATC code | L02BB |
Biological target | Androgen receptor |
Chemical class | Nonsteroidal |
Legal status | |
In Wikidata |
Close