Naive B cell
B cell not yet exposed to an antigen / From Wikipedia, the free encyclopedia
In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils, spleen, and primary lymphoid follicles in lymph nodes.
![Cells morphing into other cells (Naive B cell to plasma cell)](http://upload.wikimedia.org/wikipedia/commons/thumb/e/e9/B_cell_activation_naive_to_plasma_cell.png/320px-B_cell_activation_naive_to_plasma_cell.png)
Once exposed to an antigen, the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound. Plasma cells do not last long in the circulation; this is in contrast to memory cells that last for very long periods of time. Memory cells do not secrete antibodies until activated by their specific antigen. [1][2]