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NAPQI
Toxic byproduct of acetaminophen / From Wikipedia, the free encyclopedia
NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen).[1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.
Quick Facts Clinical data, Other names ...
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Other names | N-Acetyl-p-benzoquinone imine; N-Acetylimidoquinone |
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ECHA InfoCard | 100.168.312 ![]() |
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Formula | C8H7NO2 |
Molar mass | 149.149 g·mol−1 |
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However, under some conditions in which NAPQI is not effectively detoxified (usually in the case of paracetamol overdose), it causes severe damage to the liver. This becomes apparent 3–4 days after ingestion and may result in death from fulminant liver failure several days after the overdose.