Miconazole
Chemical compound / From Wikipedia, the free encyclopedia
Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina.[2] It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot).[2] It is applied to the skin or vagina as a cream or ointment.[2][3]
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Trade names | Desenex, Monistat, Oravig, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601203 |
Routes of administration | Topical, vaginal, sublabial |
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Bioavailability | <1% after application to the skin |
Protein binding | 88.2% |
Metabolism | CYP3A4 |
Elimination half-life | 20–25 hrs |
Excretion | Mainly feces |
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ECHA InfoCard | 100.041.188 |
Chemical and physical data | |
Formula | C18H14Cl4N2O |
Molar mass | 416.12 g·mol−1 |
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Chirality | Racemic mixture |
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Common side effects include itchiness or irritation of the area in which it was applied.[2] Use in pregnancy is believed to be safe for the baby.[4] Miconazole is in the imidazole family of medications.[2] It works by decreasing the ability of fungi to make ergosterol, an important part of their cell membrane.[2]
Miconazole was patented in 1968 and approved for medical use in 1971.[5] It is on the World Health Organization's List of Essential Medicines.[6]