MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers).[5] This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament that forms the sarcomeres in cardiac muscle and plays a major role in cardiac muscle contraction.[6]
Quick Facts Available structures, PDB ...
MYH7 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_Protein_MYH7_image.jpg/250px-PBB_Protein_MYH7_image.jpg) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3DTP, 4DB1, 4P7H, 4XA1, 4XA3, 4XA4, 4XA6, 4PA0, 5CHX, 5CJ0, 5CJ4, 5CJ1, 2FXO, 2FXM |
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Identifiers |
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Aliases | MYH7, CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin, heavy chain 7, cardiac muscle, beta, myosin heavy chain 7 |
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External IDs | OMIM: 160760; MGI: 2155600; HomoloGene: 68044; GeneCards: MYH7; OMA:MYH7 - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - apex of heart
- muscle of thigh
- Skeletal muscle tissue of biceps brachii
- gastrocnemius muscle
- right ventricle
- left ventricle
- glutes
- triceps brachii muscle
- myocardium of left ventricle
- vastus lateralis muscle
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| Top expressed in | - soleus muscle
- atrioventricular valve
- endocardial cushion
- ankle
- plantaris muscle
- cardiac muscle tissue of left ventricle
- extraocular muscle
- thoracic diaphragm
- intercostal muscle
- internal carotid artery
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| More reference expression data |
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BioGPS | |
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Wikidata |
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