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L-gulonolactone oxidase
Enzyme involved in the synthesis of vitamin C / From Wikipedia, the free encyclopedia
"GULO" redirects here. For other uses, see Gulo (disambiguation).
L-Gulonolactone oxidase (EC 1.1.3.8) is an enzyme that produces vitamin C. It is expressed in mice and rats, but is non-functional in Haplorrhini (a suborder of primates, including humans), in some bats, and in guinea pigs. It catalyzes the reaction of L-gulono-1,4-lactone with oxygen to form L-xylo-hex-3-gulonolactone (2-keto-gulono-γ-lactone) and hydrogen peroxide. It uses FAD as a cofactor. The L-xylo-hex-3-gulonolactone then converts to ascorbic acid spontaneously, without enzymatic action.The structure of L-gulonolactone oxidase in rats helps identify characteristics of this enzyme.
Quick Facts GULOP, Identifiers ...
GULOP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | GULOP, GULO, SCURVY, gulonolactone (L-) oxidase, pseudogene | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1353434; GeneCards: GULOP; OMA:GULOP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Quick Facts L-gulonolactone oxidase, Identifiers ...
L-gulonolactone oxidase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.3.8 | ||||||||
CAS no. | 9028-78-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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