Fexofenadine
Antihistamine medication / From Wikipedia, the free encyclopedia
Fexofenadine, sold under the brand name Allegra among others,[10] is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria.[11]
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Trade names | Allegra, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697035 |
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Routes of administration | By mouth |
Drug class | Antihistamine; H1 receptor antagonist |
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Bioavailability | 30–41%[8] |
Protein binding | 60–70%[9] |
Metabolism | Hepatic (≤5% of dose)[9] |
Elimination half-life | 14.4 hours |
Excretion | Feces (~80%) and urine (~10%) as unchanged drug[9] |
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ECHA InfoCard | 100.228.648 |
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Formula | C32H39NO4 |
Molar mass | 501.667 g·mol−1 |
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Chirality | Racemic mixture |
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Therapeutically, fexofenadine is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and cause sedation, compared to first-generation antihistamines.[12][13]
It was patented in 1979 and came into medical use in 1996.[14] It is on the World Health Organization's List of Essential Medicines.[15] Fexofenadine has been manufactured in generic form since 2011.[16] In 2021, it was the 262nd most commonly prescribed medication in the United States, with more than 1 million prescriptions.[17][18]