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Enoyl-CoA hydratase
Class of enzymes / From Wikipedia, the free encyclopedia
Enoyl-CoA hydratase (ECH) or crotonase[1] is an enzyme EC 4.2.1.17 that hydrates the double bond between the second and third carbons on 2-trans/cis-enoyl-CoA:[2]
Quick Facts Identifiers, Symbol ...
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | |||||||
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![]() Enoyl-CoA hydratase hexamer from a rat with active site in orange and substrate in red. | |||||||
Identifiers | |||||||
Symbol | EHHADH | ||||||
Alt. symbols | ECHD | ||||||
NCBI gene | 1962 | ||||||
HGNC | 3247 | ||||||
OMIM | 607037 | ||||||
RefSeq | NM_001966 | ||||||
UniProt | Q08426 | ||||||
Other data | |||||||
EC number | 4.2.1.17 | ||||||
Locus | Chr. 3 q26.3-q28 | ||||||
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ECH is essential to metabolizing fatty acids in beta oxidation to produce both acetyl CoA and energy in the form of ATP.[2]
ECH of rats is a hexameric protein (this trait is not universal, but human enzyme is also hexameric), which leads to the efficiency of this enzyme as it has 6 active sites. This enzyme has been discovered to be highly efficient, and allows people to metabolize fatty acids into energy very quickly. In fact this enzyme is so efficient that the rate for short chain fatty acids is equivalent to that of diffusion-controlled reactions.[3]