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Docosatetraenoic acid
Chemical compound / From Wikipedia, the free encyclopedia
Docosatetraenoic acid designates any straight chain 22:4 fatty acid. (See Essential fatty acid for nomenclature.)
Quick Facts Names, Identifiers ...
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Names | |
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Preferred IUPAC name
(7Z,10Z,13Z,16Z)-Docosa-7,10,13,16-tetraenoic acid | |
Identifiers | |
3D model (JSmol) |
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CompTox Dashboard (EPA) |
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Properties | |
C22H36O2 | |
Molar mass | 332.5 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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One isomer is of particular interest:
- all-cis-7,10,13,16-docosatetraenoic acid is an ω-6 fatty acid with the common name adrenic acid (AdA). This is a naturally occurring polyunsaturated fatty acid formed through a 2-carbon chain elongation of arachidonic acid. It is one of the most abundant fatty acids in the early human brain.[1] This unsaturated fatty acid is also metabolized by cells to biologically active products viz., dihomoprostaglandins,[2] and epoxydocosatrienoic acids (EDTs, also known as dihomo-EETs).[3] [4] [5] In addition to being endothelium-derived hyperpolarizing factors, EDTs have demonstrated anti-endoplasmic reticulum stress and anti-nociceptive activities. They are hydrolyzed by the soluble epoxide hydrolase (sEH) to dihydroxydocosatrienoic acids (DHDTs) and hence might play a role in the efficacy of sEH inhibitors.