Disulfiram-alcohol reaction
Medical condition / From Wikipedia, the free encyclopedia
Disulfiram-alcohol reaction (DAR) is the effect of the interaction in the human body of alcohol drunk with disulfiram or some mushrooms.[1][2] The DAR is key to disulfiram therapy that is widely used for alcohol-aversive treatment and management of other addictions (e.g. cocaine[3][4] use).[5][6] Once disulfiram-treated patients take alcohol, even in small doses, they experience strong unpleasant sensations (flush, nausea, lightheadedness, headache, sweating, vomiting, and vertigo).[7]
Quick Facts Other names, Specialty ...
Disulfiram-alcohol reaction (DAR) | |
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Other names | Disulfiram ethanol reaction (DER), Antabuse effect, acetaldehyde syndrome |
Alcohol flush reaction is a visible effect of DAR. | |
Specialty | Toxicology |
Symptoms | Flush, nausea, lightheadedness, headache, sweating, vomiting, vertigo, etc |
Causes | Ingestion of disulfiram with alcohol |
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Disulfiram has been used to treat alcoholism since 1948 after its accidental discovery in Denmark.[8][9][10]