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Dishevelled
Family of proteins / From Wikipedia, the free encyclopedia
Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh (Dvl in mammals) is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.[1] It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.[2] There are vertebrate homologs in zebrafish, Xenopus (Xdsh), mice (Dvl1, -2, -3) and humans (DVL-1, -2, -3). Dsh relays complex Wnt signals in tissues and cells, in normal and abnormal contexts.[2] [3] It is thought to interact with the SPATS1 protein when regulating the Wnt Signalling pathway.[4]
Dishevelled specific domain | |||||||||||
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Identifiers | |||||||||||
Symbol | Dishevelled | ||||||||||
Pfam | PF02377 | ||||||||||
InterPro | IPR003351 | ||||||||||
PROSITE | PDOC50841 | ||||||||||
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Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.[2]