DNA damage-inducible transcript 3
Human protein and coding gene / From Wikipedia, the free encyclopedia
DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. [5][6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [6] The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis and has an important role in the cell's stress response. [6]
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