Cripto is an EGF-CFC or epidermal growth factor-CFC, which is encoded by the Cryptic family 1 gene.[5] Cryptic family protein 1B is a protein that in humans is encoded by the CFC1B gene.[6][7] Cryptic family protein 1B acts as a receptor for the TGF beta signaling pathway. It has been associated with the translation of an extracellular protein for this pathway.[5] The extracellular protein which Cripto encodes plays a crucial role in the development of left and right division of symmetry.[8]
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Crypto is a glycosylphosphatidylinositol-anchored co-receptor that binds nodal and the activin type I ActRIB (ALK)-4 receptor (ALK4).[5][9][10]