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Conotoxin
Group of neurotoxins / From Wikipedia, the free encyclopedia
A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus.
This article is missing information about genetic and architectural classification (ConoServer and PMC4278219). (April 2019) |
Quick Facts Alpha conotoxin precursor, Identifiers ...
Alpha conotoxin precursor | |||||||||
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![]() α-Conotoxin PnIB from C. pennaceus, disulfide bonds shown in yellow. From the University of Michigan's Orientations of Proteins in Membranes database, PDB: 1AKG. | |||||||||
Identifiers | |||||||||
Symbol | Toxin_8 | ||||||||
Pfam | PF07365 | ||||||||
InterPro | IPR009958 | ||||||||
PROSITE | PDOC60004 | ||||||||
SCOP2 | 1mii / SCOPe / SUPFAM | ||||||||
OPM superfamily | 148 | ||||||||
OPM protein | 1akg | ||||||||
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Quick Facts Omega conotoxin, Identifiers ...
Omega conotoxin | |||||||||
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![]() Schematic diagram of the three-dimensional structure of ω-conotoxin MVIIA (ziconotide). Disulfide bonds are shown in gold. From PDB: 1DW5. | |||||||||
Identifiers | |||||||||
Symbol | Conotoxin | ||||||||
Pfam | PF02950 | ||||||||
InterPro | IPR004214 | ||||||||
SCOP2 | 2cco / SCOPe / SUPFAM | ||||||||
OPM superfamily | 112 | ||||||||
OPM protein | 1fyg | ||||||||
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Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of which have not been determined. However, it appears that many of these peptides modulate the activity of ion channels.[1] Over the last few decades conotoxins have been the subject of pharmacological interest.[2]