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Clusterin
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
In humans, clusterin (CLU) is encoded by the CLU gene on chromosome 8.[5] CLU is an extracellular molecular chaperone which binds to misfolded proteins in body fluids to neutralise their toxicity and mediate their cellular uptake by receptor-mediated endocytosis. Once internalised by cells, complexes between CLU and misfolded proteins are trafficked to lysosomes where they are degraded. [6] CLU is involved in many diseases including neurodegenerative diseases, cancers, inflammatory diseases, and aging.[7][8][9]
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