Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis.[5] In humans, cathepsin B is encoded by the CTSB gene.[6][7] Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions.[8][9][10][11]
Quick Facts CTSB, Available structures ...
CTSB |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/PDB_1csb_EBI.jpg/250px-PDB_1csb_EBI.jpg) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3PBH, 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M |
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Identifiers |
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Aliases | CTSB, APPS, CPSB, cathepsin B, RECEUP |
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External IDs | OMIM: 116810; MGI: 88561; HomoloGene: 37550; GeneCards: CTSB; OMA:CTSB - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - stromal cell of endometrium
- right lobe of thyroid gland
- left lobe of thyroid gland
- appendix
- canal of the cervix
- gallbladder
- ectocervix
- smooth muscle tissue
- olfactory zone of nasal mucosa
- monocyte
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| Top expressed in | - stroma of bone marrow
- calvaria
- white adipose tissue
- subcutaneous adipose tissue
- epithelium of stomach
- brown adipose tissue
- tibiofemoral joint
- tunica adventitia of aorta
- decidua
- lactiferous gland
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| More reference expression data |
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BioGPS | |
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Wikidata |
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