Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign compounds in mammals.[5]
Quick Facts Available structures, PDB ...
CYP2E1 |
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Identifiers |
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Aliases | CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1 |
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External IDs | OMIM: 124040; MGI: 88607; HomoloGene: 68089; GeneCards: CYP2E1; OMA:CYP2E1 - orthologs |
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EC number | 1.14.13.n7 |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right lobe of liver
- right hemisphere of cerebellum
- body of pancreas
- right frontal lobe
- right uterine tube
- skin of leg
- skin of abdomen
- endothelial cell
- middle temporal gyrus
- Brodmann area 9
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| Top expressed in | - left lobe of liver
- tunica adventitia of aorta
- white adipose tissue
- right kidney
- lactiferous gland
- subcutaneous adipose tissue
- intercostal muscle
- human kidney
- ankle joint
- tunica media of zone of aorta
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function |
- iron ion binding
- oxygen binding
- arachidonic acid epoxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- metal ion binding
- monooxygenase activity
- heme binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- enzyme binding
- oxidoreductase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
- steroid hydroxylase activity
- Hsp70 protein binding
- Hsp90 protein binding
| Cellular component | | Biological process | | Sources:Amigo / QuickGO |
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Wikidata |
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Close
While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of many toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.[6]
CYP2E1 protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.[7]