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CMAH
Pseudogene in humans / From Wikipedia, the free encyclopedia
Cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah) is an enzyme that is encoded by the CMAH gene.[5][6][7] In most mammals, the enzyme hydroxylates N-acetylneuraminic acid (Neu5Ac), producing N-glycolylneuraminic acid (Neu5Gc).[6] Neu5Ac and Neu5Gc are mammalian glycans that compose the glycocalyx, especially in sialoglycoproteins, which are part of the sialic acid family.[8] The CMAH equivalent in humans is a pseudogene (CMAHP);[9] there is no detectable Neu5Gc in normal human tissue.[6] This deficiency has a number of proposed effects on humans, including increased brain growth and improved self-recognition by the human immune system.[10][11] Incorporation of Neu5Gc from red meat and dairy into human tissues has been linked to chronic disease, including type-2 diabetes and chronic inflammation.[12][13]
CMAHP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CMAHP, CMAH, CSAH, cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 103227; GeneCards: CMAHP; OMA:CMAHP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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