CD3 (immunology)
Protein complex and T cell co-receptor / From Wikipedia, the free encyclopedia
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells).[1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
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Quick Facts CD3d molecule, delta, Identifiers ...
CD3d molecule, delta | |||||||
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Identifiers | |||||||
Symbol | CD3D | ||||||
Alt. symbols | T3D | ||||||
NCBI gene | 915 | ||||||
HGNC | 1673 | ||||||
OMIM | 186790 | ||||||
PDB | 1XIW | ||||||
RefSeq | NM_000732 | ||||||
UniProt | P04234 | ||||||
Other data | |||||||
Locus | Chr. 11 q23 | ||||||
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Quick Facts CD3e molecule, epsilon, Identifiers ...
CD3e molecule, epsilon | |||||||
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Identifiers | |||||||
Symbol | CD3E | ||||||
NCBI gene | 916 | ||||||
HGNC | 1674 | ||||||
OMIM | 186830 | ||||||
RefSeq | NM_000733 | ||||||
UniProt | P07766 | ||||||
Other data | |||||||
Locus | Chr. 11 q23 | ||||||
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Quick Facts CD3g molecule, gamma, Identifiers ...
CD3g molecule, gamma | |||||||
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Identifiers | |||||||
Symbol | CD3G | ||||||
NCBI gene | 917 | ||||||
HGNC | 1675 | ||||||
OMIM | 186740 | ||||||
RefSeq | NM_000073 | ||||||
UniProt | P09693 | ||||||
Other data | |||||||
Locus | Chr. 11 q23 | ||||||
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