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C2 domain
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A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity.[2][3]
Quick Facts Identifiers, Symbol ...
C2 domain | |||||||||
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![]() The C2-domain of C.absonum α-toxin (PDB 1OLP). β-strands are shown in yellow, α-helices in red, loops in green. Co-ordinated calcium ions are in cyan. | |||||||||
Identifiers | |||||||||
Symbol | C2 | ||||||||
Pfam | PF00168 | ||||||||
InterPro | IPR000008 | ||||||||
SMART | C2 | ||||||||
PROSITE | PDOC00380 | ||||||||
SCOP2 | 1qas / SCOPe / SUPFAM | ||||||||
OPM superfamily | 45 | ||||||||
OPM protein | 1ugk | ||||||||
CDD | cd00030 | ||||||||
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Quick Facts Phosphoinositide 3-kinase C2, Identifiers ...
Phosphoinositide 3-kinase C2 | |||||||||||
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![]() Structure of phosphoinositide 3-kinase.[1] | |||||||||||
Identifiers | |||||||||||
Symbol | PI3K_C2 | ||||||||||
Pfam | PF00792 | ||||||||||
InterPro | IPR002420 | ||||||||||
SMART | PI3K_C2 | ||||||||||
PROSITE | PDOC50004 | ||||||||||
SCOP2 | 1e8x / SCOPe / SUPFAM | ||||||||||
CDD | cd08380 | ||||||||||
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