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Angiotensin-converting enzyme
Mammalian protein found in humans / From Wikipedia, the free encyclopedia
Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.[5]
Not to be confused with Angiotensin-converting enzyme 2 (ACE2).
Quick Facts Identifiers, EC no. ...
![]() Angiotensin-converting enzyme monomer, Drosophila melanogaster | |||||||||
Identifiers | |||||||||
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EC no. | 3.4.15.1 | ||||||||
CAS no. | 9015-82-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Quick Facts ACE, Available structures ...
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Other lesser known functions of ACE are degradation of bradykinin,[6] substance P[7] and amyloid beta-protein.[8]