Ameloblastic fibro-odontoma
Medical condition / From Wikipedia, the free encyclopedia
The ameloblastic fibro-odontoma (AFO) is essentially a benign tumor with the features characteristic of ameloblastic fibroma along with enamel and dentin (hard tissues).[4] Though it is generally regarded as benign, there have been cases of its malignant transformation into ameloblastic fibrosarcoma[5] and odontogenic sarcoma.[6] Cahn LR and Blum T, believed in "maturation theory", which suggested that AFO was an intermediate stage and eventually developed during the period of tooth formation to a complex odontoma thus, being a hamartoma.[7]
Ameloblastic fibro-odontoma | |
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Specialty | Dentistry. |
Symptoms | Tooth eruption failure.[1] |
Complications | Sinus destruction, facial disfigurement, perforated cortical plates.[2] |
Usual onset | First and second decade of life.[3] |
Frequency | Rare. |
World Health Organization (WHO) defines AFO as a neoplasm consisting of odontogenic ectomesenchyme resembling the dental papilla, epithelial strands and nest resembling dental lamina and enamel organ conjunction with the presence of dentine and enamel. There is a consensus that AFO should be grouped under Odontomas. This is because once the hard tissues start forming it will eventually lead to formation of Odontomas.[8] The Recent WHO classification published in 2017
has grouped AFDs into odontomes.[9][10] According to Tekkesin S et al, combination of age and lesion size should be used to distinguish between lesions of a true neoplastic nature and hamartomatous formation.[11]