Adenosine
Chemical compound / From Wikipedia, the free encyclopedia
Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside building blocks of RNA (and its derivative deoxyadenosine is a building block of DNA), which are essential for all life on Earth. Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine monophosphate (cAMP) is pervasive in signal transduction. Adenosine is used as an intravenous medication for some cardiac arrhythmias.
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Trade names | Adenocard; Adenocor; Adenic; Adenoco; Adeno-Jec; Adenoscan; Adenosin; Adrekar; Krenosin |
Other names | SR-96225 (developmental code name) |
AHFS/Drugs.com | Monograph |
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(adenosine may be safe to the fetus in pregnant women) |
Routes of administration | Intravenous |
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Bioavailability | Rapidly cleared from circulation via cellular uptake |
Protein binding | No |
Metabolism | Rapidly converted to inosine and adenosine monophosphate |
Elimination half-life | cleared plasma <30 seconds; half-life <10 seconds |
Excretion | can leave cell intact or can be degraded to hypoxanthine, xanthine, and ultimately uric acid |
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ECHA InfoCard | 100.000.354 |
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Formula | C10H13N5O4 |
Molar mass | 267.245 g·mol−1 |
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Adenosyl (abbreviated Ado or 5'-dAdo) is the chemical group formed by removal of the 5′-hydroxy (OH) group. It is found in adenosylcobalamin (an active form of vitamin B12[1]) and as a radical in the radical SAM enzymes.[2]