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5.8S ribosomal RNA
RNA component of the large subunit of the eukaryotic ribosome / From Wikipedia, the free encyclopedia
In molecular biology, the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in ribosome translocation.[1] It is also known to form covalent linkage to the p53 tumour suppressor protein.[2] 5.8S rRNA can be used as a reference gene for miRNA detection.[3] The 5.8S ribosomal RNA is used to better understand other rRNA processes and pathways in the cell.[4]
5.8S ribosomal RNA | |
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![]() Predicted secondary structure and sequence conservation of 5.8S ribosomal RNA | |
Identifiers | |
Symbol | 5_8S_rRNA |
Rfam | RF00002 |
Other data | |
RNA type | Gene; rRNA |
Domain(s) | Eukaryota; Archaea[citation needed] |
GO | GO:0003735 GO:0005840 |
SO | SO:0000375 |
PDB structures | PDBe |
The 5.8S rRNA is homologous to the 5' end of non-eukaryotic LSU rRNA. In eukaryotes, the insertion of ITS2 breaks LSU rRNA into 5.8S and 28S rRNAs.[5] Some flies have their 5.8 rRNA further split into two pieces.[6]