The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization and reduction of firing rate of the postsynaptic neuron. In humans, the serotonin 1A receptor is encoded by the HTR1A gene.[5][6]
Quick Facts HTR1A, Identifiers ...
HTR1A |
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Identifiers |
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Aliases | HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A |
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External IDs | OMIM: 109760; MGI: 96273; HomoloGene: 20148; GeneCards: HTR1A; OMA:HTR1A - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - entorhinal cortex
- middle temporal gyrus
- Brodmann area 46
- superior vestibular nucleus
- superior frontal gyrus
- hippocampus proper
- prefrontal cortex
- endothelial cell
- Brodmann area 23
- dorsolateral prefrontal cortex
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| Top expressed in | - ventral nuclear group
- subthalamus
- ventral nucleus of lateral geniculate body
- ventral posterolateral nucleus
- ventral posteromedial nucleus
- medial habenular nucleus
- zona incerta
- lateral habenular nucleus
- thalamic reticular nucleus
- ventral lateral nucleus
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BioGPS | |
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Wikidata |
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