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3C-like protease
Class of enzymes / From Wikipedia, the free encyclopedia
See also: COVID-19 drug development
The 3C-like protease (3CLpro) or main protease (Mpro), formally known as C30 endopeptidase or 3-chymotrypsin-like protease,[2] is the main protease found in coronaviruses. It cleaves the coronavirus polyprotein at eleven conserved sites. It is a cysteine protease and a member of the PA clan of proteases. It has a cysteine-histidine catalytic dyad at its active site and cleaves a Gln–(Ser/Ala/Gly) peptide bond.
Quick Facts Identifiers, EC no. ...
![]() SARS-CoV-2 main proteinase dimer with the catalytic dyad (H41; C145) in complex with a covalent peptidomimetic protease inhibitor ("11a", magenta). From PDB: 6LZE.[1] | |||||||||
Identifiers | |||||||||
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EC no. | 3.4.22.69 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Quick Facts Peptidase C30, Coronavirus endopeptidase, Identifiers ...
Peptidase C30, Coronavirus endopeptidase | |||||||||
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Identifiers | |||||||||
Symbol | Peptidase_C30 | ||||||||
Pfam | PF05409 | ||||||||
InterPro | IPR008740 | ||||||||
PROSITE | PS51442 | ||||||||
MEROPS | C30 | ||||||||
SCOP2 | d1q2wb1 / SCOPe / SUPFAM | ||||||||
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The Enzyme Commission refers to this family as SARS coronavirus main proteinase (Mpro; EC 3.4.22.69). The 3CL protease corresponds to coronavirus nonstructural protein 5 (nsp5). The "3C" in the common name refers to the 3C protease (3Cpro) which is a homologous protease found in picornaviruses.