Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme.[5] Thrombomodulin is also expressed on human mesothelial cell,[6] monocyte and a dendritic cell subset.
Quick Facts THBD, Available structures ...
THBD |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS |
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Identifiers |
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Aliases | THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3 |
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External IDs | OMIM: 188040 MGI: 98736 HomoloGene: 308 GeneCards: THBD |
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Wikidata |
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