Tetrahydrocortisol
Chemical compound / From Wikipedia, the free encyclopedia
Tetrahydrocortisol, or urocortisol, also known as 3α,11β,17α,21-tetrahydroxy-5β-pregnan-20-one, is a steroid and an inactive metabolite of cortisol.[1]
Quick Facts Names, Identifiers ...
Names | |
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IUPAC name
3α,11β,17,21-Tetrahydroxy-5β-pregnan-20-one | |
Systematic IUPAC name
2-Hydroxy-1-(1R,3aS,3bS,5aR,7R,9aS,9bS,10S,11aS)-1,7,10-trihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]ethan-1-one | |
Other names
Urocortisol; 3α,5β-Tetrahydrocortisol; 3α,5β-Cortisol | |
Identifiers | |
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3D model (JSmol) |
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ChEBI | |
ChemSpider |
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ECHA InfoCard | 100.000.146 |
PubChem CID |
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UNII | |
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Properties | |
C21H34O5 | |
Molar mass | 366.49 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Tetrahydrocortisol is a neurosteroid and has been found to act as a negative allosteric modulator of the GABAA receptor, similarly to pregnenolone sulfate.[2][3][4]