Suramin
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Suramin is a medication used to treat African sleeping sickness and river blindness.[1][2] It is the treatment of choice for sleeping sickness without central nervous system involvement.[3] It is given by injection into a vein.[4]
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Trade names | Antrypol, 309 Fourneau, Bayer 205, others |
AHFS/Drugs.com | Drugs.com archive |
Routes of administration | by injection only |
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ECHA InfoCard | 100.005.145 |
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Formula | C51H40N6O23S6 |
Molar mass | 1297.26 g·mol−1 |
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Suramin causes a fair number of side effects.[4] Common side effects include nausea, vomiting, diarrhea, headache, skin tingling, and weakness.[2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur.[2] Severe side effects may include low blood pressure, decreased level of consciousness, kidney problems, and low blood cell levels.[4] It is unclear if it is safe when breastfeeding.[2]
Suramin was made at least as early as 1916.[5] It is on the World Health Organization's List of Essential Medicines.[6] In the United States it can be acquired from the Centers for Disease Control (CDC).[3] In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO).[7]