SARM1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Sterile alpha and TIR motif containing 1 Is an enzyme that in humans is encoded by the SARM1 gene. It is the most evolutionarily conserved member of the Toll/Interleukin receptor-1 (TIR) family.[5][6] SARM1's TIR domain has intrinsic NADase enzymatic activity that is highly conserved from archaea, plants, nematode worms, fruit flies, and humans.[7][8][9] In mammals, SARM1 is highly expressed in neurons, where it resides in both cell bodies and axons, and can be associated with mitochondria.[10]
Quick Facts Identifiers, Aliases ...
SARM1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SARM1, MyD88-5, SAMD2, SARM, sterile alpha and TIR motif containing 1, hHsTIR | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607732; MGI: 2136419; HomoloGene: 9015; GeneCards: SARM1; OMA:SARM1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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