Prothrombin complex concentrate
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Prothrombin complex concentrate (PCC), also known as factor IX complex, sold under the brand name Kcentra among others, is a combination medication made up of blood clotting factors II, IX, and X.[9] Some versions also contain factor VII.[10] It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available.[9][11] It may also be used for reversal of warfarin therapy.[11] It is given by slow injection into a vein.[9]
Combination of | |
---|---|
Factor II | Blood clotting factor |
Factor VII | Blood clotting factor |
Factor IX | Blood clotting factor |
Factor X | Blood clotting factor |
Clinical data | |
Trade names | Kcentra, others |
Other names | factor IX complex |
AHFS/Drugs.com | Monograph Monograph |
License data | |
Routes of administration | Intravenous |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
DrugBank |
Common side effects include allergic reactions, headache, vomiting, and sleepiness.[9][12] Other serious side effects include blood clots which may result in a heart attack, stroke, pulmonary embolism, or deep vein thrombosis.[12] Antibodies may form after long term use such that future doses are less effective.[11]
Prothrombin complex concentrate came into medical use in the 1960s.[13] It is on the World Health Organization's List of Essential Medicines.[14][15] It is made from human plasma.[12] Recombinant factor IX is also available in a stand-alone preparation.[16]