Prefoldin subunit 3
Chaperone protein / From Wikipedia, the free encyclopedia
Prefoldin subunit 3 (VBP-1),[1] also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[2] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[3]
Quick Facts Identifiers, Symbol ...
Prefoldin subunit 3 | |||||||
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Identifiers | |||||||
Symbol | VBP1 | ||||||
NCBI gene | 7411 | ||||||
HGNC | 12662 | ||||||
OMIM | 300133 | ||||||
RefSeq | NM_003372 | ||||||
UniProt | P61758 | ||||||
Other data | |||||||
Locus | Chr. X q28 | ||||||
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VBP-1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[3] and is a member of the prefoldin-α subunit family.[4] It is ubiquitously expressed in tissues, and is located in the cell nucleus and cytoplasm.[4] The VBP1 gene is located at Xq28.[5] Homologues are known to exist between human VBP-1 and proteins in mice, Drosophila and C. elegans.[3]