Ornithine decarboxylase
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The enzyme ornithine decarboxylase (EC 4.1.1.17, ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. This reaction is the committed step in polyamine synthesis.[1] In humans, this protein has 461 amino acids and forms a homodimer.[2]
Quick Facts Identifiers, EC no. ...
Ornithine decarboxylase | |||||||||
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Identifiers | |||||||||
EC no. | 4.1.1.17 | ||||||||
CAS no. | 9024-60-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
ornithine decarboxylase | |||||||
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Identifiers | |||||||
Symbol | ODC1 | ||||||
NCBI gene | 4953 | ||||||
HGNC | 8109 | ||||||
OMIM | 165640 | ||||||
RefSeq | NM_002539 | ||||||
UniProt | P11926 | ||||||
Other data | |||||||
EC number | 4.1.1.17 | ||||||
Locus | Chr. 2 p25 | ||||||
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In humans, ornithine decarboxylase (ODC) is expressed by the gene ODC1. The protein ODC is sometimes referred to as "ODC1" in research pertaining to humans and mice, but certain species such as Drosophila (dODC2),[3] species of Solanaceae plant family (ODC2),[4] and the lactic acid bacteria Paucilactobacillus wasatchensis (odc2)[5] have been shown to have a second ODC gene.