Nimodipine
Antihypertensive drug of the calcium channel blocker class / From Wikipedia, the free encyclopedia
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Nimodipine, sold under the brand name Nimotop among others, is a calcium channel blocker used in preventing vasospasm secondary to subarachnoid hemorrhage (a form of cerebral hemorrhage). It was originally developed within the calcium channel blocker class as it was used for the treatment of high blood pressure, but is not used for this indication.
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Nimotop, Nymalize, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a689010 |
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Routes of administration | Intravenous, by mouth |
Drug class | Dihydropyridine calcium channel blocker |
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Pharmacokinetic data | |
Bioavailability | 13% (by mouth) |
Protein binding | 95% |
Metabolism | Hepatic |
Elimination half-life | 8–9 hours |
Excretion | Feces and Urine |
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ECHA InfoCard | 100.060.096 |
Chemical and physical data | |
Formula | C21H26N2O7 |
Molar mass | 418.446 g·mol−1 |
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Melting point | 125 °C (257 °F) |
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It was patented in 1971[3] and approved for medical use in the US in 1988.[4] It was approved for medical use in Germany in 1985.[5]