Netrin receptor DCC
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene.[5] DCC has long been implicated in colorectal cancer and its previous name was Deleted in colorectal carcinoma.[6] Netrin receptor DCC is a single transmembrane receptor.
Since it was first discovered in a colorectal cancer study in 1990,[7] DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1.[8]
More recently DCC has been characterized as a dependence receptor, and many hypotheses have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.[9]