mtDNA control region
Non-coding region of the mitochondrial DNA / From Wikipedia, the free encyclopedia
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The mtDNA control region is an area of the mitochondrial genome which is non-coding DNA. This region controls RNA and DNA synthesis.[1] It is the most polymorphic region of the human mtDNA genome,[2] with polymorphism concentrated in hypervariable regions. The average nucleotide diversity in these regions is 1.7%.[3] Despite this variability, an RNA transcript from this region has a conserved secondary structure (pictured) which has been found to be under selective pressure.[4]
Mitochondrial DNA control region secondary structure A | |
---|---|
Identifiers | |
Symbol | mtDNA ssA |
Rfam | RF01853 |
Other data | |
RNA type | Antisense RNA |
Domain(s) | Mammalia |
PDB structures | PDBe |
The mtDNA control region contains the origin of replication of one strand, and the origin of transcription for both strands.[5] There is also an open reading frame thought to code for 7s ribosomal RNA in humans but not in mice or cows, where it has been deleted.[6]