Miconazole
Chemical compound / From Wikipedia, the free encyclopedia
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Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina.[2] It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot).[2] It is applied to the skin or vagina as a cream or ointment.[2][3]
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Trade names | Desenex, Monistat, Oravig, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601203 |
Routes of administration | Topical, vaginal, sublabial |
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Bioavailability | <1% after application to the skin |
Protein binding | 88.2% |
Metabolism | CYP3A4 |
Elimination half-life | 20–25 hrs |
Excretion | Mainly feces |
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ECHA InfoCard | 100.041.188 |
Chemical and physical data | |
Formula | C18H14Cl4N2O |
Molar mass | 416.12 g·mol−1 |
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Chirality | Racemic mixture |
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Common side effects include itchiness or irritation of the area in which it was applied.[2] Use in pregnancy is believed to be safe for the baby.[4] Miconazole is in the imidazole family of medications.[2] It works by decreasing the ability of fungi to make ergosterol, an important part of their cell membrane.[2]
Miconazole was patented in 1968 and approved for medical use in 1971.[5] It is on the World Health Organization's List of Essential Medicines.[6]