Mexiletine
Pair of enantiomers / From Wikipedia, the free encyclopedia
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Mexiletine (INN) (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea. It works as a non-selective voltage-gated sodium channel blocker and belongs to the Class IB group of anti-arrhythmic medications.[2]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Mexitil, NaMuscla |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607064 |
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Routes of administration | By mouth, intravenous |
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Pharmacokinetic data | |
Bioavailability | 90% |
Protein binding | 50–60% |
Metabolism | Liver (CYP2D6 and 1A2-mediated) |
Elimination half-life | 10–12 hours |
Excretion | Kidney (10%) |
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ECHA InfoCard | 100.046.190 |
Chemical and physical data | |
Formula | C11H17NO |
Molar mass | 179.263 g·mol−1 |
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Chirality | Racemic mixture |
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