Methylprednisolone acetate
Chemical compound / From Wikipedia, the free encyclopedia
Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.[1][2][3][4][5][6][7] It has been formulated as an aqueous suspension for intramuscular, intra-articular, soft tissue, and intralesional injection alone and in combination with lidocaine, a local anesthetic.[1][4][5] Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity.[6][8] Depo methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection.[5]
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Trade names | Depo-Medrol, Depo-Medrate, Depo-Medrone, others |
Other names | Depot methylprednisolone acetate; Methylprednisolone 21-acetate; 6α-Methylprednisolone 21-acetate; NSC-48985 |
Routes of administration | Intramuscular injection |
Drug class | Corticosteroid; Glucocorticoid |
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ECHA InfoCard | 100.000.157 |
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Formula | C24H32O6 |
Molar mass | 416.514 g·mol−1 |
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