Meropenem
Broad-spectrum antibiotic / From Wikipedia, the free encyclopedia
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Meropenem, sold under the brand name Merrem among others, is an intravenous carbapenem antibiotic used to treat a variety of bacterial infections.[2] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[2]
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Trade names | Merrem, others |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous |
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Bioavailability | 100% |
Protein binding | Approximately 2% |
Elimination half-life | 1 hour |
Excretion | Kidney |
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ECHA InfoCard | 100.169.299 |
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Formula | C17H25N3O5S |
Molar mass | 383.46 g·mol−1 |
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Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[2] Serious side effects include Clostridioides difficile infection, seizures, and allergic reactions including anaphylaxis.[2] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well.[2] Use in pregnancy appears to be safe.[2] It is in the carbapenem family of medications.[2] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[2] It is more resistant to breakdown by β-lactamase producing bacteria.[2]
Meropenem was patented in 1983.[3] It was approved for medical use in the United States in 1996.[2] It is on the World Health Organization's List of Essential Medicines.[4][5] The World Health Organization classifies meropenem as critically important for human medicine.[6]