Hydroxycarbamide
Medication / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Hydroxycarbamide?
Summarize this article for a 10 year old
Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer.[3][4] In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks.[3] It is taken by mouth.[3]
Clinical data | |
---|---|
Trade names | Droxia, Hydrea, Siklos, others |
Other names | Hydroxyurea (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682004 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Metabolism | Liver (to CO2 and urea) |
Elimination half-life | 2–4 hours |
Excretion | Kidney and lungs |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
NIAID ChemDB | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.004.384 |
Chemical and physical data | |
Formula | CH4N2O2 |
Molar mass | 76.055 g·mol−1 |
3D model (JSmol) | |
Melting point | 133 to 136 °C (271 to 277 °F) |
| |
| |
(verify) |
Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches.[3][4] There is also concern that it increases the risk of later cancers.[3] Use during pregnancy is typically harmful to the fetus.[3] Hydroxycarbamide is in the antineoplastic family of medications. It is believed to work by blocking the making of DNA.[3]
Hydroxycarbamide was approved for medical use in the United States in 1967.[3] It is on the World Health Organization's List of Essential Medicines.[5] Hydroxycarbamide is available as a generic medication.[3]