Gap-43 protein
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Growth Associated Protein 43 (GAP43) is a protein encoded by the GAP43 gene[5] in humans.
Quick Facts GAP43, Available structures ...
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Aliases | GAP43, B-50, PP46, growth associated protein 43, GAP-43 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 162060; MGI: 95639; HomoloGene: 1545; GeneCards: GAP43; OMA:GAP43 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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GAP43 is called a "growth" or "plasticity" protein because it is expressed at high levels in neuronal growth cones during development[6] and axonal regeneration, and it is phosphorylated after long-term potentiation and after learning.[citation needed]
GAP43 is a crucial component of the axon and presynaptic terminal. Its null mutation leads to death within days after birth, due to axon pathfinding defects.[7]