Fosfomycin
Chemical compound / From Wikipedia, the free encyclopedia
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Fosfomycin, sold under the brand name Monurol among others, is an antibiotic primarily used to treat lower urinary tract infections.[7] It is not indicated for kidney infections.[7] Occasionally it is used for prostate infections.[7] It is generally taken by mouth.[7]
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Trade names | Monuril, Monurol, Ivozfo, others |
Other names | Phosphomycin, phosphonomycin, fosfomycin tromethamine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697008 |
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Routes of administration | Intravenous, By mouth |
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Bioavailability | 30–37% (by mouth, fosfomycin tromethamine); varies with food intake |
Protein binding | Nil |
Metabolism | Nil |
Elimination half-life | 5.7 hours (mean) |
Excretion | Kidney, unchanged |
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ECHA InfoCard | 100.041.315 |
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Formula | C3H7O4P |
Molar mass | 138.059 g·mol−1 |
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Melting point | 94 °C (201 °F) |
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Common side effects include diarrhea, nausea, headache, and vaginal yeast infections.[7] Severe side effects may include anaphylaxis and Clostridioides difficile-associated diarrhea.[7] While use during pregnancy has not been found to be harmful, such use is not recommended.[8] A single dose when breastfeeding appears safe.[8] Fosfomycin works by interfering with the production of the bacterial cell wall.[7]
Fosfomycin was discovered in 1969 and approved for medical use in the United States in 1996 [globalize].[7][9] It is on the World Health Organization's List of Essential Medicines.[10] The World Health Organization classifies fosfomycin as critically important for human medicine.[11] It is available as a generic medication.[12] It was originally produced by certain types of Streptomyces, although it is now made chemically.[9]