Fexinidazole
Oral anti-parasitic medical drug / From Wikipedia, the free encyclopedia
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Fexinidazole is a medication used to treat African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense.[3] It is effective against both first and second stage disease.[3] Also a potential new treatment for Chagas disease, a neglected tropical disease that affects millions of people worldwide.[4] It is taken by mouth.[5]
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Routes of administration | By mouth |
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ECHA InfoCard | 100.207.619 |
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Formula | C12H13N3O3S |
Molar mass | 279.31 g·mol−1 |
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Common side effects include nausea, vomiting, headache, and trouble sleeping.[6] Other side effects may include QT prolongation, psychosis, and low white blood cells.[7] It is unclear if use during pregnancy or breast feeding is safe.[7] Fexinidazole is in the antiparasitic and the nitroimidazole family of medications.[5] It is believed to work by turning on certain enzymes within the parasites that result in their death.[6]
Fexinidazole was first described in 1978.[8] It was given a positive opinion by the European Medicines Agency in 2018.[6] It is on the World Health Organization's List of Essential Medicines.[9][10] Development for sleeping sickness was funded by the Drugs for Neglected Diseases initiative in collaboration with Sanofi.[11] Fexinidazole was approved for medical use in the United States in July 2021.[1]