Dentinogenesis imperfecta
Medical condition / From Wikipedia, the free encyclopedia
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Dentinogenesis imperfecta (DI) is a genetic disorder of tooth development. It is inherited in an autosomal dominant pattern, as a result of mutations on chromosome 4q21, in the dentine sialophosphoprotein gene (DSPP).[1][2][3][4][5] It is one of the most frequently occurring autosomal dominant features in humans.[6] Dentinogenesis imperfecta affects an estimated 1 in 6,000-8,000 people.[7]
Dentinogenesis imperfecta | |
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Oral photographs from an individual with Dentinogenesis imperfecta | |
Specialty | Dentistry |
This condition can cause teeth to be discolored (most often a blue-gray or yellow-brown color) and translucent, giving teeth an opalescent sheen.[2][3][8][5][9] Teeth are also weaker than normal, making them prone to rapid wear, breakage, and loss.[2][3][4][5][8] These problems can affect baby (primary/deciduous) teeth alone, or both baby teeth and adult (permanent) teeth, with the baby teeth usually more severely affected.[5][8]
Although genetic factors are the main contributor for the disease, any environmental or systemic upset that impedes calcification or metabolisation of calcium can also result in anomalous dentine.