Cytotoxic T-lymphocyte associated protein 4
Mammalian protein found in humans / From Wikipedia, the free encyclopedia
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Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers.[5] It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. It is encoded by the gene CTLA4 in humans.
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The CTLA-4 protein is encoded by the Ctla-4 gene in mice.[6][7]