Copper fist
From Wikipedia, the free encyclopedia
Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist closed around a penny. Functionally, the "penny" is a collection of copper ions and the "knuckles" of the fist are proteins that interact with the promoter of the metallothionein gene,[1] enhancing its transcription by creating a more stable binding site for RNA polymerase during transcription, an essential step in DNA replication.[2]