Clavulanic acid
Molecule used to overcome antibiotic resistance in bacteria / From Wikipedia, the free encyclopedia
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Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
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Pronunciation | /ˌklævjʊˈlænɪk/ |
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Routes of administration | Oral, IV |
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Bioavailability | "Well absorbed" |
Metabolism | Hepatic (extensive) |
Elimination half-life | 1 hour |
Excretion | Renal (30–40%) |
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ECHA InfoCard | 100.055.500 |
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Formula | C8H9NO5 |
Molar mass | 199.162 g·mol−1 |
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In its most common preparations, potassium clavulanate (clavulanic acid as a salt of potassium) is combined with:
- amoxicillin (co-amoxiclav, trade names Augmentin, Clavulin, Tyclav, Clavaseptin (veterinary), Clavamox (veterinary), Synulox (veterinary), and others)
- ticarcillin (co-ticarclav, trade name Timentin)
Clavulanic acid was patented in 1974.[1]