Ceftolozane/tazobactam
Antibiotic / From Wikipedia, the free encyclopedia
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Ceftolozane/tazobactam, sold under the brand name Zerbaxa, is a fixed-dose combination antibiotic medication used for the treatment of complicated urinary tract infections and complicated intra-abdominal infections in adults.[5][4][6] Ceftolozane is a cephalosporin antibiotic, developed for the treatment of infections with gram-negative bacteria that are resistant to conventional antibiotics.[7] It was studied for urinary tract infections, intra-abdominal infections and ventilator-associated bacterial pneumonia.
Combination of | |
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Ceftolozane | Cephalosporin antibiotic |
Tazobactam | Beta-lactamase inhibitor |
Clinical data | |
Trade names | Zerbaxa |
AHFS/Drugs.com | Monograph |
MedlinePlus | a615010 |
License data | |
Pregnancy category |
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Routes of administration | Intravenous |
ATC code | |
Legal status | |
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Identifiers | |
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ChemSpider | |
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Chemical and physical data | |
Formula | C23H30N12O8S2 |
Molar mass | 666.69 g·mol−1 |
3D model (JSmol) | |
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The most common side effects include nausea (feeling sick), headache, constipation, diarrhea and fever.[4][6]
Ceftolozane is a type of antibiotic called a cephalosporin, which belongs to the wider group of antibiotics called beta-lactams.[4] It works by interfering with the production of molecules that bacteria need to build their protective cell walls.[4] This causes weakness in the bacterial cell walls which then become prone to collapse, ultimately leading to the death of the bacteria.[4]
Tazobactam blocks the action of bacterial enzymes called beta-lactamases.[4] These enzymes enable bacteria to break down beta-lactam antibiotics like ceftolozane, making the bacteria resistant to the antibiotic's action.[4] By blocking the action of these enzymes, tazobactam allows ceftolozane to act against bacteria that would otherwise be resistant to ceftolozane.[4]
Ceftolozane is combined with the β-lactamase inhibitor tazobactam, which protects ceftolozane from degradation.[8] It was approved for medical use in the United States in December 2014,[6][9] and in the European Union in September 2015.[4] It is on the World Health Organization's List of Essential Medicines.[10]